In addition to the above, you can remove their ability to access your computer across the network by removing their user right. You should also not share folders, run a Web server on your computer, run remote administration programs (see your domain admins), run antiviral software to prevent Trojans and apply file and folder access permissions. Nothing can stop a determined attacker forever, but you can certainly build in layers of security that will defend your data files from your fellow workers.
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You should also seek help from your information security staff. If you are having a problem with fellow workers destroying data files or abusing system privilges, security should be made aware.
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