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Adjusting security settings in Internet Explorer 6.0

Windows security threats expert Kevin Beaver helps a user adjust their security settings Internet Explorer 6.0.

When I go to Internet Explorer 6.0, then Tools, then Internet options, the Apply button is disabled so I can't make any changes to the Internet options. I've been told that it has to do with my security template. My question is where in the security template is that Apply button being disabled?
There's a chance you've been infected by some sort of malware not allowing you to change things like your home page (see this Microsoft link.) I recommend scanning your system using 2-3 anti-spyware tools such as Spybot and Microsoft's Antispyware as well as perform a thorough virus scan. You can also run gpedit.msc to see if any IE settings have been changed/applied as shown here:

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