This tip was submitted to the SearchWin2000.com Tip Exchange by member Irwin Weisel. Let other users know how useful it is by rating the tip below.
From an administrator account, create a mailbox named "You_Are_Rejected" or something to that effect. Click the "Protocols" tab and select "Minimum Protocol Usage." Then, go to "Delivery Options" and give send permissions to the "You_Are_Rejected" mailbox and select "Enable None" for your alternate.
From the "Delivery Restrictions" tab, select "Accept All and Reject None." Insert the spammer's e-mail address (alias@domainname,) as an SMTP. For every Exchange user to whom you want this new mailbox to apply, go to "Properties > Delivery Restrictions." Configure the mailbox to reject messages from the "You_Are_Rejected" mail box. Your e-mail box will now reject any SMTP addresses listed in the "You_Are_Rejected" mailbox.
You can also select an automated response that gets sent to each spammer every time they send you an e-mail once they're added to the list.